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During meiosis, chromosomes with substantial DNA sequence homology will pair and exchange pieces of DNA, a process called genetic recombination. Learn more about SRY at:

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Patients with these syndromes and others with deletion or duplication syndromes often have parents with balanced translocations involving the chromosomes in which the child has the deletion or duplication.

Evolution of the Y Chromosome

Film Guide Teacher Guide. A "Klinefelter Calico Cat" was one of the first evidence that the Y chromosome determines maleness in mammals.

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Failure of oogenesis leading to diploid egg which begins to differentiate in the ovary involves all 3 germ layers. If it is de novo , there is a negligible risk of recurrence. Some rearrangements where there is no apparent loss of genetic material would be expected to be innocuous in the bearer, however, they turn out to be a problem during meiosis. The X and Y were able to recombine in these expanded regions of the chromosomes. Moderate to severe mental retardation; marked hypogonadism; skeletal abnormalities; congenital heart disease.
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